Tubulin, alpha 1a (Tuba1a) (N-Term) Peptide
Tuba1a
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TUBA1A (Tuba1a) products
- TUBA1A (Tuba1a) (Tubulin, alpha 1a (Tuba1a))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NACWELYCLE HGIQPDGQMP SDKTIGGGDD SFNTFFSETG AGKHVPRAVF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- TUBA1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TUBA1A (Tuba1a) (Tubulin, alpha 1a (Tuba1a))
- Background
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Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: LIS3, TUBA3, B-ALPHA-1
Protein Size: 335 - Gene ID
- 7846
- NCBI Accession
- NM_001270399, NP_001257328
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