Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) Peptide
ErbB2/Her2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5673015
Quick Overview for Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) Peptide (ABIN5673015)
Target
ErbB2/Her2
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- DPTVPLPSET DGYVAPLTCS PQPEYVNQPD VRPQPPSPRE GPLPAARPAG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- ERBB2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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Background
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This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Alias Symbols: NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu
Protein Size: 645 -
Gene ID
- 2064
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NCBI Accession
- NM_001005862, NP_001005862
Target
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