Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide
GNA12
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5673091
Quick Overview for Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) Peptide (ABIN5673091)
Target
GNA12
(Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- IILFLNKMDL LVEKVKTVSI KKHFPDFRGD PHRLEDVQRY LVQCFDRKRR
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- GNA12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
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Background
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Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Alias Symbols: RMP, gep, NNX3
Protein Size: 381 -
Gene ID
- 2768
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NCBI Accession
- NM_001282441, NP_001269370
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UniProt
- Q03113
Target
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