Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (Middle Region) Peptide
RASSF1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5673474
Quick Overview for Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) (Middle Region) Peptide (ABIN5673474)
Target
RASSF1
(Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- IKVQLKLVRP VSVPSSKKPP SLQDARRGPG RGTSVRRRTS FYLPKDAVKH
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- RASSF1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
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Background
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This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: 123F2, RDA32, NORE2A, RASSF1A, REH3P21
Protein Size: 344 -
Gene ID
- 11186
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NCBI Accession
- NM_001206957, NP_001193886
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UniProt
- Q9NS23
Target
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