Sestrin 1 (SESN1) (Middle Region) Peptide
SESN1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SESN1 products
- SESN1 (Sestrin 1 (SESN1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ESMFVFSSDD EEVTPARAVS RHFEDTSYGY KDFSRHGMHV PTFRVQDYCW
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- SESN1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SESN1 (Sestrin 1 (SESN1))
- Background
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This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: PA26, SEST1
Protein Size: 551 - Gene ID
- 27244
- NCBI Accession
- NM_001199933, NP_001186862
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