Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 662-1014) Peptide
PARP1
Reactivity: Human
Host: Escherichia coli (E. coli)
SDS
Dithiothreitol (DTT)
1 image
Catalog No. ABIN935086
Quick Overview for Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 662-1014) Peptide (ABIN935086)
Target
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
Origin
Human
Source
Escherichia coli (E. coli)
Application
SDS-PAGE (SDS)
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Peptide Type
- Recombinant
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Protein Region
- AA 662-1014
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Sequence
- MKSKLPKPVQ DLIKMIFDVE SMKKAMVEYE IDLQKMPLGK LSKRQIQAAY SILSEVQQAV SQGSSDSQIL DLSNRFYTLI PHDFGMKKPP LLNNADSVQA KAEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD IKVVDRDSEE AEIIRKYVKN THATTHNAYD LEVIDIFKIE REGECQRYKP FKQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG LGKTTPDPSA NISLDGVDVP LGTGISSGVN DTSLLYNEYI VYDIAQVNLK YLLKLKFNFK TSLW
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Characteristics
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Purified recombinant Human PARP1 protein
Expression System: E.coli -
Purity
- > 95 % pure
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Application Notes
- PARP1 protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Supplied as a liquid in 20 mM Tris buffer, pH 8.0, containing 10 % glycerol and 0 mM DTT.
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Preservative
- Dithiothreitol (DTT)
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Precaution of Use
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
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Background
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PARP1 is a nuclear DNA-binding zinc finger protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP1 also plays a role in other cellular processes, including cell proliferation and differentiation. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADPribosyl)ation contributes to the efficient maintenance of genome integrity. Recombinant PARP1 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: PARP1 protein, Poly (ADP-ribose) polymerase family protein, NAD(+) ADP ribosyltransferase 1 protein, member 1 ADP ribosyltransferase (NAD+ protein, pADPRT-1 protein, sPARP1., PARP-1 protein, PPOL protein, Poly[ADP ribose] synthetase 1 protein, ADPRT1 protein, poly(ADP ribose) synthetase protein, Poly (ADP ribose) polymerase 1 protein, poly(ADP ribosyl)transferase protein, ADPRT 1 protein, PARP 1 protein, ADPRT protein, poly (ADP ribose) polymerase) protein, PARP 1, PARP1, sPARP 1 protein, msPARP protein, pADPRT protein, PARP protein, pADPRT 1 protein, PARP 1 protein, PARP-1, PARP-1 protein -
Molecular Weight
- 39.6 kDa (354 AA)
Target
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