Cathepsin C (CTSC) Peptide
CTSC
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN935975
Quick Overview for Cathepsin C (CTSC) Peptide (ABIN935975)
Target
CTSC
(Cathepsin C (CTSC))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- WTATTYMEYE TLTLGDMIRR SGGHSRKIPR PKPAPLTAEI QQKILHLPTS
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of CTSC antibody,
Alternative Names: CTSC control peptide, CTSC antibody Blocking Peptide, Anti-CTSC Blocking Peptide, cathepsin C Blocking Peptide, CPPI Blocking Peptide, DPP1 Blocking Peptide, DPPI Blocking Peptide, HMS Blocking Peptide, JP Blocking Peptide, JPD Blocking Peptide, PALS Blocking Peptide, PLS Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- CTSC (Cathepsin C (CTSC))
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Background
- CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
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Molecular Weight
- 8 kDa
Target
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