Methyl-CpG Binding Domain Protein 2 (MBD2) Peptide
MBD2
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN937259
Quick Overview for Methyl-CpG Binding Domain Protein 2 (MBD2) Peptide (ABIN937259)
Target
MBD2
(Methyl-CpG Binding Domain Protein 2 (MBD2))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- DCPALPPGWK KEEVIRKSGL SAGKSDVYYF SPSGKKFRSK PQLARYLGNT
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of MBD2 antibody,
Alternative Names: MBD2 control peptide, MBD2 antibody Blocking Peptide, Anti-MBD2 Blocking Peptide, Methyl-Cpg Binding Domain Protein 2 Blocking Peptide, MBD2, MBD-2, MBD 2, MBD-2 Blocking Peptide, MBD 2 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))
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Background
- MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation signal. It is also reported that the MBD2 functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development.
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Molecular Weight
- 32 kDa
Target
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