Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Peptide
TDP1
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN938152
Quick Overview for Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Peptide (ABIN938152)
Target
TDP1
(Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- ETNVYLIGST PGRFQGSHRD NWGHFRLRKL LQAHAPSTPK GECWPIVGQF
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of Tdp1 antibody,
Alternative Names: Tdp1 control peptide, Tdp1 antibody Blocking Peptide, Anti-Tdp1 Blocking Peptide, tyrosyl-DNA phosphodiesterase 1 Blocking Peptide, 2810481F14Rik Blocking Peptide, 4921509N21Rik Blocking Peptide, AI838772 Blocking Peptide, AW493413 Blocking Peptide, E430034L06Rik Blocking Peptide, SCAN1 Blocking Peptide, Tdp1, Tdp-1, Tdp 1, Tdp-1 Blocking Peptide, Tdp 1 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))
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Background
- Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate.
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Molecular Weight
- 64 kDa
Target
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