Mitochondrial Antiviral Signaling Protein (MAVS) Peptide
MAVS
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN938153
Quick Overview for Mitochondrial Antiviral Signaling Protein (MAVS) Peptide (ABIN938153)
Target
MAVS
(Mitochondrial Antiviral Signaling Protein (MAVS))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- ETQAPESPGE NSEQALQTLS PRAIPRNPDG GPLESSSDLA ALSPLTSSGH
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of VISA antibody,
Alternative Names: VISA control peptide, VISA antibody Blocking Peptide, Anti-VISA Blocking Peptide, Virus-Induced Signaling Adapter Blocking Peptide, CARDIF Blocking Peptide, DKFZp666M015 Blocking Peptide, FLJ27482 Blocking Peptide, FLJ41962 Blocking Peptide, IPS-1 Blocking Peptide, KIAA1271 Blocking Peptide, MAVS Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
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Background
- Double-stranded RNA viruses are recognised in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA.
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Molecular Weight
- 56 kDa
Target
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