Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptide
EGLN3
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
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- Target See all EGLN3 products
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Peptide Type
- Synthetic
- Origin
- Mammalian
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- FWSDRRNPHE VQPSYATRYA MTVWYFDAEE RAEAKKKFRN LTRKTESALT
- Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of EGLN3 antibody,
Alternative Names: EGLN3 control peptide, EGLN3 antibody Blocking Peptide, Anti-EGLN3 Blocking Peptide, Egl Nine Homolog 3 Blocking Peptide, FLJ21620 Blocking Peptide, HIFPH3 Blocking Peptide, MGC125998 Blocking Peptide, MGC125999 Blocking Peptide, PHD3 Blocking Peptide
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- Application Notes
- Optimal conditions should be determined by the investigator
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
- Buffer
- PBS
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C long term.
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- Target
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
- Background
- EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
- Molecular Weight
- 27 kDa
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