Iron-Responsive Element Binding Protein 2 (IREB2) Peptide
IREB2
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN939499
Quick Overview for Iron-Responsive Element Binding Protein 2 (IREB2) Peptide (ABIN939499)
Target
IREB2
(Iron-Responsive Element Binding Protein 2 (IREB2))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- IQINLNSIVP SVSGPKRPQD RVAVTDMKSD FQACLNEKVG FKGFQIAAEK
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of IREB2 antibody,
Alternative Names: IREB2 control peptide, IREB2 antibody Blocking Peptide, Anti-IREB2 Blocking Peptide, Iron-Responsive Element Binding Protein 2 Blocking Peptide, ACO3 Blocking Peptide, FLJ23381 Blocking Peptide, IRP2 Blocking Peptide, IRP2AD Blocking Peptide, IREB2, IREB-2, IREB 2, IREB-2 Blocking Peptide, IREB 2 Blocking Peptide
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))
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Background
- IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
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Molecular Weight
- 105 kDa
Target
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