Toll-Like Receptor 4 (TLR4) Peptide
TLR4
Reactivity: Mammalian
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN940355
Quick Overview for Toll-Like Receptor 4 (TLR4) Peptide (ABIN940355)
Target
TLR4
(Toll-Like Receptor 4 (TLR4))
Origin
Mammalian
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Peptide Type
- Synthetic
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Sequence
- LGEFRNEGNL EKFDKSALEG LCNLTIEEFR LAYLDYYLDD IIDLFNCLTN
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Characteristics
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A synthetic peptide for use as a blocking control in assays to test for specificity of TLR4 antibody,
Alternative Names: TLR4 control peptide, TLR4 antibody Blocking Peptide, Anti-TLR4 Blocking Peptide, toll-like receptor 4 Blocking Peptide, ARMD10 Blocking Peptide, CD284 Blocking Peptide, TOLL Blocking Peptide, hToll Blocking Peptide, TLR4, TLR-4, TLR 4, TLR-4 Blocking Peptide, TLR 4 Blocking Peptide
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Toll-Like Receptor 4 (TLR4) (AA 420-435) peptide (Ovalbumin)
TLR4 Reactivity: Human Host: Synthetic WB, Imm, SDS
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Application Notes
- Optimal conditions should be determined by the investigator
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
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Buffer
- PBS
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- -20 °C
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Storage Comment
- Store at -20 °C long term.
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- TLR4 (Toll-Like Receptor 4 (TLR4))
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Background
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
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Molecular Weight
- 93 kDa
Target
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