Adrenergic, alpha-1B-, Receptor (ADRA1B) (C-Term) Peptide
ADRA1B
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for Adrenergic, alpha-1B-, Receptor (ADRA1B) (C-Term) Peptide (ABIN972959)
Target
ADRA1B
(Adrenergic, alpha-1B-, Receptor (ADRA1B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- YRPWTRGGSL ERSQSRKDSL DDSGSCLSGS QRTLPSASPS PGYLGRGAPP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ADRA1B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ADRA1B (Adrenergic, alpha-1B-, Receptor (ADRA1B))
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Background
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Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
Alias Symbols: ADRA1, ALPHA1BAR
Protein Interaction Partner: ADRA1A,AP2M1,EZR,FLNC,GNA11,GNAQ,NOS1,PRKCA,SAG,STAT1,AP2M1
Protein Size: 520 -
Molecular Weight
- 57 kDa
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Gene ID
- 147
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NCBI Accession
- NM_000679, NP_000670
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UniProt
- P35368
Target
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