Alpha-2A Adrenergic Receptor (ADRA2A) (C-Term) Peptide
ADRA2A
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for Alpha-2A Adrenergic Receptor (ADRA2A) (C-Term) Peptide (ABIN972962)
Target
ADRA2A
(Alpha-2A Adrenergic Receptor (ADRA2A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- RRPERGPRGK GKARASQVKP GDSLPRRGPG ATGIGTPAAG PGEERVGAAK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ADRA2A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))
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Background
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Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons, the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
Alias Symbols: ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Protein Size: 450 -
Molecular Weight
- 49 kDa
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Gene ID
- 150
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NCBI Accession
- NM_000681, NP_000672
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UniProt
- P08913
Target
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