Autoimmune Regulator (AIRE) Peptide
AIRE
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN973041
Quick Overview for Autoimmune Regulator (AIRE) Peptide (ABIN973041)
Target
AIRE
(Autoimmune Regulator (AIRE))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-AIRE antibody (Catalog #: ARP32650_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AIRE (Autoimmune Regulator (AIRE))
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Background
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The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1
Protein Interaction Partner: AIRE,CREBBP,AIRE,CREBBP,AIRE,CHD6,CREBBP,DDX17,DDX5,EFTUD2,GEMIN5,HIST1H2AC,HIST1H2BO,IPO7,KPNB1,LMNB1,MCM2,MCM5,MCM6,MSH2,MSH6,MYBBP1A,NASP,NOP56,NUP93,PABPC1,PARP1,PCNA,POLR2A,POLR2B,PRKDC,RAD21,RANBP2,RANBP9,RUVBL2,SMC1A,SMC3,SNRPB,SNRPD3,SRSF1,SRSF2,SRSF3,SSRP1,TOP2A,TRIM28,XPO1,XPOT
Protein Size: 545 -
Molecular Weight
- 58 kDa
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Gene ID
- 326
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NCBI Accession
- NM_000383, NP_000374
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UniProt
- O43918
Target
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