Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2) (Middle Region) Peptide
AOC2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973271
Quick Overview for Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2) (Middle Region) Peptide (ABIN973271)
Target
AOC2
(Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-AOC2 antibody (Catalog #: ARP45057_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AOC2 (Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2))
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Background
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Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.
Alias Symbols: DAO2, RAO
Protein Size: 756 -
Molecular Weight
- 84 kDa
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Gene ID
- 314
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NCBI Accession
- NM_009590, NP_033720
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UniProt
- O75106
Target
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