Apelin Receptor (APLNR) (N-Term) Peptide
APLNR
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Apelin Receptor (APLNR) products
- Apelin Receptor (APLNR)
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LAKLKKKKGP STVTDLEDTK RDRSVDVNGG PEPAPASTSA VSTPSPSADL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-APLNR Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Apelin Receptor (APLNR)
- Background
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AP2A2 is a component of the adaptor protein complex 2 (AP-2). AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .
Alias Symbols: AGTRL1, APJ, APJR, FLJ90771, FLJ96609, HG11, MGC45246
Protein Interaction Partner: RALBP1,AMPH,AP1S1,AP2A2,AP2B1,BIN1,DNAJC6,DNM1,EPN1,EPS15,HTT,NUMB,SHC1,SMAD1,SNAP91,AMPH,ATM,ATR,CLTC,DAB2,EPN1,EPS15,HTT,SHC1
Protein Size: 939 - Molecular Weight
- 104 kDa
- Gene ID
- 187
- NCBI Accession
- NM_005161, NP_005152
- UniProt
- P35414
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