Arrestin, beta 2 (ARRB2) Peptide
ARRB2
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN973461
Quick Overview for Arrestin, beta 2 (ARRB2) Peptide (ABIN973461)
Target
Arrestin 3 (ARRB2)
(Arrestin, beta 2 (ARRB2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ARRB2 antibody (Catalog #: ARP48007_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Arrestin, beta 2 (ARRB2) peptide
ARRB2 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Arrestin 3 (ARRB2) (Arrestin, beta 2 (ARRB2))
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Background
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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. ARRB2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Alias Symbols: ARB2, ARR2, DKFZp686L0365, BARR2
Protein Interaction Partner: NFKBIA,PDE4D,SLC9A5,AGTR1,AP1B1,ARF6,AVPR2,C5AR1,CLTC,CSNK2A1,CSNK2A2,CXCR4,CYTH2,DVL2,FLNA,FZD4,HIPK3,HTR2C,MAP3K5,MAPK1,MAPK10,MDM2,MED8,NDUFS7,NFKBIA,NTS,NTSR1,OPRD1,OXTR,PTAFR,RAF1,RALGDS,SLC9A5,SMARCC2,STC2,TGFBR3,TRH,AP2B1,AP3B1,ARF6,ARRB1,AVPR2,BOP1,CYTH2,DDX27,FBL,ITCH,KPNA3,KPNA4,LHCGR,MAP2K4,MAP3K5,MAPK10,MAPK3,MDM2,MED8,MRPL43,MRPL44,NEDD4,NOLC1,OPRD1,PES1,PTAFR,RAB5C,RALGDS,RPL7L1,SMARCC2,SMO,STC2,TCOF1
Protein Size: 394 -
Molecular Weight
- 44 kDa
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Gene ID
- 409
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NCBI Accession
- NM_199004, NP_945355
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UniProt
- P32121
Target
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