Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) Peptide
ASCL1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN973496
Quick Overview for Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1) Peptide (ABIN973496)
Target
ASCL1
(Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ASCL1 antibody (Catalog #: ARP32355_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))
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Background
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ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers.
Alias Symbols: ASH1, HASH1, MASH1, bHLHa46
Protein Interaction Partner: ASCL1,BMP2,EP300,MEF2A,NEUROG2,TCF4,UBQLN1,EP300,MEF2A,TCF4
Protein Size: 236 -
Molecular Weight
- 25 kDa
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Gene ID
- 429
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NCBI Accession
- NM_004316, NP_004307
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UniProt
- P50553
Target
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