BCL2-Associated Athanogene 3 (BAG3) (Middle Region) Peptide
BAG3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all BAG3 products
- BAG3 (BCL2-Associated Athanogene 3 (BAG3))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BAG3 antibody (Catalog #: ARP48251_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BAG3 (BCL2-Associated Athanogene 3 (BAG3))
- Background
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BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BAG-3, BIS, CAIR-1, MGC104307
Protein Interaction Partner: BCL2,BCL2,DAZAP2,DVL2,FAM189A2,HSPA1A,HSPA8,HSPB8,PLCG1,AMOT,DAZAP2,DVL2,FAM189A2,HSPA1A,HSPA8,HSPB8,PLCG1
Protein Size: 575 - Molecular Weight
- 61 kDa
- Gene ID
- 9531
- NCBI Accession
- NM_004281, NP_004272
- UniProt
- O95817
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