B-Cell CLL/lymphoma 2 (BCL2) (Middle Region) Peptide
BCL2
Reactivity: Human
Host: Synthetic
BP, WB
Quick Overview for B-Cell CLL/lymphoma 2 (BCL2) (Middle Region) Peptide (ABIN973780)
Target
Bcl-2 (BCL2)
(B-Cell CLL/lymphoma 2 (BCL2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- ALSPVPPVVH LTLRQAGDDF SRRYRRDFAE MSSQLHLTPF TARGRFATVV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BCL2 Antibody(ARP58872_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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B-Cell CLL/lymphoma 2 (BCL2) peptide
BCL2 Reactivity: Human, Mouse, Rat, Dog Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Background
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This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Alias Symbols: Bcl-2, PPP1R50
Protein Interaction Partner: BAD,BAD,BAX,BBC3,BCL2L11,BID,BIK,BIK,BMF,BNIPL,HRK,HRK,RHEB,MOAP1,ATP2A2,BAD,BAG1,BAG3,BAG4,BAK1,BAX,BBC3,BCAP31,BCL2,BCL2L1,BCL2L10,BCL2L11,BCL2L14,BCLAF1,BECN1,BFAR,BID,BIK,BLK,BMF,BNIP1,BNIP2,BNIP3,BNIP3L,BNIPL,CASP3,CASP8,CDK2,CPT1A,CYCS,FKBP8,HRAS,HR
Protein Size: 239 -
Molecular Weight
- 26 kDa
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Gene ID
- 596
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NCBI Accession
- NM_000633, NP_000624
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UniProt
- P10415
Target
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