Baculoviral IAP Repeat-Containing 7 (BIRC7) (Middle Region) Peptide
BIRC7
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN973825
Quick Overview for Baculoviral IAP Repeat-Containing 7 (BIRC7) (Middle Region) Peptide (ABIN973825)
Target
BIRC7
(Baculoviral IAP Repeat-Containing 7 (BIRC7))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BIRC7 antibody (Catalog #: AVARP02033_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BIRC7 (Baculoviral IAP Repeat-Containing 7 (BIRC7))
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Background
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BIRC7 protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
Alias Symbols: KIAP, LIVIN, ML-IAP, MLIAP, RNF50
Protein Interaction Partner: CASP3,CASP7,CASP9,DIABLO,HTRA2,CASP3,CASP7,CASP9,XAF1
Protein Size: 298 -
Molecular Weight
- 33 kDa
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Gene ID
- 79444
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NCBI Accession
- NM_139317, NP_647478
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UniProt
- Q96CA5
Target
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