Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Middle Region) Peptide
CASP4
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974475
Quick Overview for Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) (Middle Region) Peptide (ABIN974475)
Target
Caspase 4 (CASP4)
(Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CASP4 Antibody(ARP58990_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4) peptide
CASP4 Reactivity: Human, Cow, Cat, Dog, Mouse Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
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Background
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This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Alias Symbols: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Protein Interaction Partner: PSEN1,APAF1,APP,CASP10,CASP14,CASP3,CASP4,DSP,IL18,IL1B,NOD1,PLA2G4A,PSEN1,SERPINB9,APAF1,CASP1,CASP10,CASP14,CASP8,CDK2,CTNNBIP1,EIF2S3,GCN1L1,GSN,HEATR2,IL18,IL1F7,KIAA0776,MSH6,MTHFD1L,MYCBPAP,NOD1,NUP93,PSMB1,SLC25A22,SMC1A,SMC2,SMC3,SRPRB,USP9X,VDAC3
Protein Size: 377 -
Molecular Weight
- 10 kDa
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Gene ID
- 837
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NCBI Accession
- NM_001225, NP_001216
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UniProt
- P49662
Target
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