Chemokine (C-C Motif) Receptor 5 (CCR5) (Middle Region) Peptide
CCR5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974625
Quick Overview for Chemokine (C-C Motif) Receptor 5 (CCR5) (Middle Region) Peptide (ABIN974625)
Target
CCR5
(Chemokine (C-C Motif) Receptor 5 (CCR5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CCR5 antibody (Catalog #: ARP30788_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))
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Background
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CCR5 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this protein was also detected in a promyeloblastic cell line, suggesting that CCR5 may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
Protein Interaction Partner: ADRBK1,ADRBK2,AFP,ARL6IP5,ARRB1,CCL11,CCL13,CCL14,CCL16,CCL2,CCL3,CCL3L1,CCL3L3,CCL4,CCL5,CCL7,CCL8,CCR2,CCR5,CD4,CXCR4,DNM2,GNAI1,GNAI2,GNAI3,GNAO1,GNAQ,JAK1,JAK2,LCK,ORM1,PRAF2,PSMA5,PTK2,PTK2B,STAT1,STAT3,STAT5A,TXK,AFP,ARRB1,CCL3,CCL3L1,CCL5,CD4,CXCR4,JAK2,PIK3R2,PTK2,STAT3,STAT5B
Protein Size: 352 -
Molecular Weight
- 41 kDa
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Gene ID
- 1234
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NCBI Accession
- NM_000579, NP_000570
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UniProt
- P51681
Target
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