Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Peptide
CDKN1B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974784
Quick Overview for Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Peptide (ABIN974784)
Target
CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CDKN1B antibody (Catalog #: AVARP03039_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
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Background
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CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Protein Interaction Partner: FOXO3,CCNA1,CCNA2,CCNA2,CCNA2,CCND1,CCNE1,CCNE1,CDK2,CDK2,CDK2,COPS5,E1A,E1A,KPNA2,SKP2,SKP2,STMN1,UBB,XPO1,ABL1,AKT1,ARHGDIA,CASP8,CCNA1,CCNA2,CCNB1,CCND1,CCND2,CCND3,CCNE2,CDK2,CDK3,CDK4,CDK5,CKS1B,COPS5,CUL4A,GRB2,KPNA3,KPNA5,LYN,MCM7,NUP50,SKP2,SRC,STMN1,TRAF2,TSC2,UBB,UCHL1,XPO1,YES1,YWHAB,YWHAE,YWHAG,YWHAH,YWHAQ,AKT1,ARHGDIA,CCNA1,CCNA2,CCND1,CCND2,CCND3,CCNE1,CDC34,CDK2,CDK4,CDK6,CKS1B,COPS5,CUL4A,GRB2,NUP50,SKP2,SPDYA,TRAF2,TSC1,TSC2,UBE2B,UBE2D2,UCHL1,XPO1,YWHAQ
Protein Size: 198 -
Molecular Weight
- 22 kDa
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Gene ID
- 1027
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NCBI Accession
- NM_004064, NP_004055
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UniProt
- P46527
Target
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