Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) (N-Term) Peptide
CHRNA4
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974950
Quick Overview for Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4) (N-Term) Peptide (ABIN974950)
Target
CHRNA4
(Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHRNA4 antibody (Catalog #: AVARP13015_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHRNA4 (Cholinergic Receptor, Nicotinic, alpha 4 (CHRNA4))
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Background
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CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BFNC, EBN, EBN1, NACRA4, NACHR, NACHRA4
Protein Interaction Partner: CHRNB2,CHRNB2,CHRNB4,CRELD2,UBQLN1,VSNL1,YWHAH,YWHAH
Protein Size: 627 -
Molecular Weight
- 70 kDa
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Gene ID
- 1137
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NCBI Accession
- NM_000744, NP_000735
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UniProt
- P43681
Target
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