Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) Peptide
CHRNB2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN974960
Quick Overview for Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) Peptide (ABIN974960)
Target
CHRNB2
(Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CHRNB2 antibody (Catalog #: ARP37669_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) peptide
CHRNB2 Reactivity: Human, Cow, Dog, Mouse, Pig, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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Background
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Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Alias Symbols: EFNL3, nAChRB2
Protein Interaction Partner: CHRNA4,CHRNA2,CHRNA4,CRELD2
Protein Size: 502 -
Molecular Weight
- 57 kDa
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Gene ID
- 1141
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NCBI Accession
- NM_000748, NP_000739
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UniProt
- P17787
Target
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