Chymase 1, Mast Cell (CMA1) (C-Term) Peptide
CMA1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975101
Quick Overview for Chymase 1, Mast Cell (CMA1) (C-Term) Peptide (ABIN975101)
Target
CMA1
(Chymase 1, Mast Cell (CMA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- EVKLRLMDPQ ACSHFRDFDH NLQLCVGNPR KTKSAFKGDS GGPLLCAGVA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CMA1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CMA1 (Chymase 1, Mast Cell (CMA1))
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Background
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CMA1 is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies.
Alias Symbols: CYH, MCT1, MGC119890, MGC119891, chymase
Protein Interaction Partner: AGT,EDN1,EDN2,EDN3,KITLG,MMP1,PFN1,SERPINA3
Protein Size: 247 -
Molecular Weight
- 27 kDa
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Gene ID
- 1215
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NCBI Accession
- NM_001836, NP_001827
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UniProt
- P23946
Target
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