COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2) Peptide
COPS2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all COPS2 products
- COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-COPS2 antibody (Catalog #: ARP34188_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))
- Background
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COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Alias Symbols: ALIEN, CSN2, SGN2, TRIP15
Protein Interaction Partner: COPS2,COPS4,COPS6,GPS1,COPS2,COPS3,COPS4,COPS5,COPS6,COPS7A,COPS8,CUL5,GFER,GPS1,IRF8,MAPK8,NIF3L1,NR0B1,NR2F1,RARA,RXRA,THRA,THRB,TP53,COPS5,COPS6,COPS8,CPSF1,CUL4A,DDB1,EcR,IRF8,KLHL13,NIF3L1,NR0B1,NR2F1,SIN3A,Sin3a,THRA,THRB,Thrb,UIMC1,WDR8
Protein Size: 443 - Molecular Weight
- 52 kDa
- Gene ID
- 9318
- NCBI Accession
- NM_004236, NP_004227
- UniProt
- P61201
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