Cystatin B (Stefin B) (CSTB) (N-Term) Peptide
CSTB
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975393
Quick Overview for Cystatin B (Stefin B) (CSTB) (N-Term) Peptide (ABIN975393)
Target
CSTB
(Cystatin B (Stefin B) (CSTB))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- ADQVRSQLEE KENKKFPVFK AVSFKSQVVA GTNYFIKVHV GDEDFVHLRV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CSTB Antibody(ARP59177_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CSTB (Cystatin B (Stefin B) (CSTB))
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Background
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CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.
Alias Symbols: CST6, EPM1, PME, STFB, ULD, EPM1A
Protein Interaction Partner: CTSB,CTSD,CTSH,CTSL1,CST3,CTSB,CTSH,VHL
Protein Size: 98 -
Molecular Weight
- 11 kDa
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Gene ID
- 1476
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NCBI Accession
- NM_000100, NP_000091
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UniProt
- P04080
Target
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