CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) Peptide
CTCF
Reactivity: Human
Host: Synthetic
BP, WB, ChIP
Catalog No. ABIN975410
Quick Overview for CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) Peptide (ABIN975410)
Target
CTCF
(CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CTCF antibody (Catalog #: ARP38820_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
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Background
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CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
Protein Interaction Partner: EIF2S3,THRB,YBX1,HMGB1,POLR2A,SMAD3,SMAD4,THRB,YBX1,CHD7,CHD8,SUZ12,YBX1
Protein Size: 727 -
Molecular Weight
- 83 kDa
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Gene ID
- 10664
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NCBI Accession
- NM_006565, NP_006556
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UniProt
- P49711
Target
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