Cortactin (CTTN) Peptide
CTTN
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN975451
Quick Overview for Cortactin (CTTN) Peptide (ABIN975451)
Target
Cortactin (CTTN)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CTTN antibody (Catalog #: ARP52067_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Cortactin (CTTN)
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Background
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CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. CTTN is localized in the cytoplasm and in areas of the cell-substratum contacts. It has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, CTTN is degraded in a caspase-dependent manner. The aberrant regulation of t CTTN contributes to tumor cell invasion and metastasis.This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Alias Symbols: EMS1, FLJ34459
Protein Interaction Partner: ARHGAP8,ACTA1,ACTR3,ANKZF1,CHD3,CTNND1,CTNND2,CTTN,CTTNBP2,DNM1,DNM2,FER,FGD1,GRB2,HAX1,HIP1R,KCNA2,MET,MYLK,NCF1,SDC3,SHANK2,SRC,SYK,TJP1,WIPF1,ACTR2,ACTR3,ARHGAP17,ARPC2,ARPC3,ARPC4,ASAP1,CASP3,CHD3,CRB2,CTNND1,FER,KCNA2,MYLK,PXN,SDC3,SHANK2,SYK,WASL,WIPF1
Protein Size: 550 -
Molecular Weight
- 61 kDa
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Gene ID
- 2017
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NCBI Accession
- NM_005231, NP_005222
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UniProt
- Q8N707
Target
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