Dynactin 3 (p22) (Dctn3) (C-Term) Peptide
Dctn3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975638
Quick Overview for Dynactin 3 (p22) (Dctn3) (C-Term) Peptide (ABIN975638)
Target
DCTN3 (Dctn3)
(Dynactin 3 (p22) (Dctn3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- ARLQRLAQIH IQQQDQCVEI TEESKALLEE YNKTTMLLSK QFVQWDELLC
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-DCTN3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DCTN3 (Dctn3) (Dynactin 3 (p22) (Dctn3))
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Background
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This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.
Alias Symbols: DCTN-22, DCTN22, MGC111190
Protein Interaction Partner: ATXN1,DCTN1,PBX2
Protein Size: 186 -
Molecular Weight
- 20 kDa
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Gene ID
- 11258
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NCBI Accession
- NM_001248, NP_001239
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UniProt
- O75355
Target
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