Damage-Specific DNA Binding Protein 2, 48kDa (DDB2) (C-Term) Peptide
DDB2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DDB2 products
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DDB2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))
- Background
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This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
Alias Symbols: DDBB, FLJ34321, UV-DDB2
Protein Size: 427 - Molecular Weight
- 48 kDa
- Gene ID
- 1643
- NCBI Accession
- NM_000107, NP_000098
- UniProt
- Q92466
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