Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (N-Term) Peptide
DYRK1A
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all DYRK1A products
- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- INEVYYAKKK RRHQQGQGDD SSHKKERKVY NDGYDDDNYD YIVKNGEKWM
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-DYRK1A Antibody(ARP45797_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))
- Background
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This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Alias Symbols: DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Protein Interaction Partner: CREB1,PHYHIP,CCNL2,CREB1,DYRK1A,FOXO1,GLI1,PHYHIP,SF3B1,YWHAB,YWHAE,YWHAG,CCNL2,CLASRP,DCAF7,DNM1,SFN,SRSF1,SRSF4,SRSF5
Protein Size: 763 - Molecular Weight
- 85 kDa
- Gene ID
- 1859
- NCBI Accession
- NM_001396, NP_001387
- UniProt
- Q13627
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