E2F Transcription Factor 2 (E2F2) (Middle Region) Peptide
E2F2
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN976079
Quick Overview for E2F Transcription Factor 2 (E2F2) (Middle Region) Peptide (ABIN976079)
Target
E2F2
(E2F Transcription Factor 2 (E2F2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-E2F2 antibody (Catalog #: ARP38418_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- E2F2 (E2F Transcription Factor 2 (E2F2))
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Background
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E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46 % amino acid identity to E2F1.The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46 % amino acid identity to E2F1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: E2F-2
Protein Interaction Partner: E2F4,RBL2,CDC25A,CDC6,E2F1,EAPP,FHL2,GAB2,JMY,MT1G,MYBL2,PPP1R13B,RB1,RB1,RB1,RBL1,RYBP,SETD8,TP53BP2,TP53INP1,UXT,ARID3A,BCAR1,BRD2,CDK3,RB1,RYBP,SETD8,SP1,TFDP1,TFDP2,YY1,BCAR1,BRD2,FHL2,RB1,RNF144A,RYBP,SETD8,SPIB,Sp1
Protein Size: 437 -
Molecular Weight
- 47 kDa
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Gene ID
- 1870
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NCBI Accession
- NM_004091, NP_004082
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UniProt
- Q14209
Target
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