Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptide
EGLN3
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN976180
Quick Overview for Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) Peptide (ABIN976180)
Target
EGLN3
(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-EGLN3 antibody (Catalog #: ARP52402_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
-
Background
-
EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
Alias Symbols: FLJ21620, HIFPH3, MGC125998, MGC125999, PHD3
Protein Interaction Partner: HIF1A,OS9,EPAS1,HIF1A,HIF3A,OS9,WDR83
Protein Size: 239 -
Molecular Weight
- 27 kDa
-
Gene ID
- 112399
-
NCBI Accession
- NM_022073, NP_071356
-
UniProt
- Q9H6Z9
Target
-
You are here:
