Coagulation Factor XI (F11) (C-Term) Peptide
F11
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Factor XI (F11) products
- Factor XI (F11) (Coagulation Factor XI (F11))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RHLCGGSIIG NQWILTAAHC FYGVESPKIL RVYSGILNQS EIKEDTSFFG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-F11 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Factor XI (F11) (Coagulation Factor XI (F11))
- Background
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This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Alias Symbols: FXI, MGC141891
Protein Interaction Partner: F11,F2,HGF,KNG1,SERPINA5,SERPINF2,TFPI2,KNG1,SERPINA5
Protein Size: 625 - Molecular Weight
- 70 kDa
- Gene ID
- 2160
- NCBI Accession
- NM_000128, NP_000119
- UniProt
- P03951
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