Fc Fragment of IgE Receptor Ia (FCER1A) (N-Term) Peptide
FCER1A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976777
Quick Overview for Fc Fragment of IgE Receptor Ia (FCER1A) (N-Term) Peptide (ABIN976777)
Target
Fc epsilon RI/FCER1A (FCER1A)
(Fc Fragment of IgE Receptor Ia (FCER1A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- NPPWNRIFKG ENVTLTCNGN NFFEVSSTKW FHNGSLSEET NSSLNIVNAK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FCER1A Antibody(ARP45203_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))
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Background
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The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139), only the alpha subunit is glycosylated.
Alias Symbols: FCE1A, FcERI
Protein Interaction Partner: FCER1A,FCER1G,ITIH2,MS4A2,VAV1
Protein Size: 257 -
Molecular Weight
- 27 kDa
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Gene ID
- 2205
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NCBI Accession
- NM_002001, NP_001992
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UniProt
- P12319
Target
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