Fibroblast Growth Factor 2 (Basic) (FGF2) (Middle Region) Peptide
FGF2
Reactivity: Human
Host: Synthetic
WB, BP, IHC
Quick Overview for Fibroblast Growth Factor 2 (Basic) (FGF2) (Middle Region) Peptide (ABIN976833)
Target
FGF2
(Fibroblast Growth Factor 2 (Basic) (FGF2))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB), Blocking Peptide (BP), Immunohistochemistry (IHC)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FGF2 antibody (Catalog #: ARP42005_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FGF2 (Fibroblast Growth Factor 2 (Basic) (FGF2))
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Background
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The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BFGF, FGFB, HBGF-2
Protein Interaction Partner: NRP1,API5,CD44,CEP57,CSNK2A1,CSNK2A2,CSNK2B,CXCL13,FGF2,FGFBP1,FGFR1,FGFR3,FGFR4,FGFRL1,GPC3,GPC4,HSPG2,NRP1,PF4,PRMT1,PTX3,RPL6,RPS19,RPS6KA3,SDC1,SDC2,SDC3,VTN,CSNK2A1,CSNK2A2,CSNK2B,FGFBP1,FGFR1,GPC3,GPC4,RPL6,RPS19,SDC1,SDC2,SDC3,SDC4,VTN
Protein Size: 288 -
Molecular Weight
- 31 kDa
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Gene ID
- 2247
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NCBI Accession
- NM_002006, NP_001997
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UniProt
- P09038
Target
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