Fragile Histidine Triad (FHIT) (Middle Region) Peptide
FHIT
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976850
Quick Overview for Fragile Histidine Triad (FHIT) (Middle Region) Peptide (ABIN976850)
Target
FHIT
(Fragile Histidine Triad (FHIT))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VHVLPRKAGD FHRNDSIYEE LQKHDKEDFP ASWRSEEEMA AEAAALRVYF
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FHIT Antibody(ARP51169_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FHIT (Fragile Histidine Triad (FHIT))
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Background
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This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
Alias Symbols: AP3Aase, FRA3B
Protein Interaction Partner: FDXR,FHIT,GSN,HSPD1,SRC,UBE2I,FHIT,UBE2I
Protein Size: 147 -
Molecular Weight
- 17 kDa
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Gene ID
- 2272
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NCBI Accession
- NM_002012, NP_002003
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UniProt
- P49789
Target
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