General Transcription Factor II I Repeat Domain-Containing 1 (GTF2IRD1) Peptide
GTF2IRD1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN977776
Quick Overview for General Transcription Factor II I Repeat Domain-Containing 1 (GTF2IRD1) Peptide (ABIN977776)
Target
GTF2IRD1
(General Transcription Factor II I Repeat Domain-Containing 1 (GTF2IRD1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-GTF2IRD1 antibody (Catalog #: ARP33735_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GTF2IRD1 (General Transcription Factor II I Repeat Domain-Containing 1 (GTF2IRD1))
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Background
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GTF2IRD1 contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. GTF2IRD1 is related to Williams-Beuren syndrome, a multisystem developmental disorder. Western blots using three different antibodies against three unique regions of this protein target confirm the same apparent molecular weight in our tests. The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing of this gene generates at least 2 transcript variants.
Alias Symbols: CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, WBSCR12, hMusTRD1alpha1, BEN, WBS
Protein Interaction Partner: CDK20,EXOSC4,HDAC3,PIAS2,SMAD3,EXOSC4,HDAC3,HDAC3,NFI1,PIAS2,PIAS2,Pias2
Protein Size: 959 -
Molecular Weight
- 106 kDa
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Gene ID
- 9569
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NCBI Accession
- NM_016328, NP_057412
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UniProt
- Q9UHL9
Target
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