Hepatitis A Virus Cellular Receptor 2 (TIM 3) (N-Term) Peptide
TIM 3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977863
Quick Overview for Hepatitis A Virus Cellular Receptor 2 (TIM 3) (N-Term) Peptide (ABIN977863)
Target
TIM3 (TIM 3)
(Hepatitis A Virus Cellular Receptor 2 (TIM 3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HAVCR2 antibody (Catalog #: ARP45550_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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Target Type
- Virus
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Background
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HAVCR2 regulates macrophage activation. HAVCR2 inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. HAVCR2 may be also involved in T-cell homing. HAVCR2 is the receptor for LGALS9.CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-562 BC063431.1 1-562 563-1203 AF450243.1 476-1116 1204-2338 BC063431.1 1204-2338
Alias Symbols: FLJ14428, KIM-3, TIM3, TIMD3, Tim-3, TIMD-3, HAVcr-2
Protein Interaction Partner: HAVCR2
Protein Size: 301 -
Molecular Weight
- 33 kDa
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Gene ID
- 84868
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NCBI Accession
- NM_032782, NP_116171
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UniProt
- Q8TDQ0
Target
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