High Mobility Group AT-Hook 1 (HMGA1) (N-Term) Peptide
HMGA1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978048
Quick Overview for High Mobility Group AT-Hook 1 (HMGA1) (N-Term) Peptide (ABIN978048)
Target
HMGA1
(High Mobility Group AT-Hook 1 (HMGA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPKEPSEV PTPKRPRGRP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HMGA1 Antibody(ARP38111_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HMGA1 (High Mobility Group AT-Hook 1 (HMGA1))
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Background
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This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: HMG-R, HMGA1A, HMGIY, MGC12816, MGC4242, MGC4854
Protein Interaction Partner: ATF2,CDK1,CEBPB,CREBBP,CSNK2A1,CSNK2A2,ELF1,EWSR1,HIPK2,IRF1,JUN,NFYA,POU3F1,PPARG,PRMT6,RARG,RNF4,RXRA,SP1,SRF,SUFU,ATF2,BANF1,CEBPB,CHD1,ELF1,EWSR1,INSR,IRF1,JUN,NFYA,NPM1,PARP1,POU3F1,PPARG,PRMT6,SP1
Protein Size: 96 -
Molecular Weight
- 11 kDa
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Gene ID
- 3159
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NCBI Accession
- NM_002131, NP_002122
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UniProt
- Q5T6U8
Target
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