Iron-Responsive Element Binding Protein 2 (IREB2) Peptide
IREB2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978591
Quick Overview for Iron-Responsive Element Binding Protein 2 (IREB2) Peptide (ABIN978591)
Target
IREB2
(Iron-Responsive Element Binding Protein 2 (IREB2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-IREB2 antibody (Catalog #: ARP40509_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IREB2 (Iron-Responsive Element Binding Protein 2 (IREB2))
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Background
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IREB2 binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. IREB2 binds to the IRE element in ferritin which results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Alias Symbols: ACO3, FLJ23381, IRP2, IRP2AD
Protein Interaction Partner: YBX1,YBX1,YBX1
Protein Size: 963 -
Molecular Weight
- 105 kDa
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Gene ID
- 3658
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NCBI Accession
- NM_004136, NP_004127
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UniProt
- P48200
Target
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