Lysine (K)-Specific Demethylase 4B (KDM4B) (Middle Region) Peptide
KDM4B
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978699
Quick Overview for Lysine (K)-Specific Demethylase 4B (KDM4B) (Middle Region) Peptide (ABIN978699)
Target
KDM4B
(Lysine (K)-Specific Demethylase 4B (KDM4B))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-JMJD2B antibody (Catalog #: ARP58398_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KDM4B (Lysine (K)-Specific Demethylase 4B (KDM4B))
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Background
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JMJD2 family proteins are classified into one group with JD2H and TUDOR domains and another group without JD2H or TUDOR domains. Because JMJD2C gene (also known as GASC1 gene) is amplified in esophageal squamous cell carcinoma (ESCC), JMJD2 family genes are cancer-associated genes. Human genes corresponding to KIAA0677, KIAA0876, KIAA0780 and FLJ10251 cDNAs were designated JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. In addition, JMJD2D homologous genes within human genome sequences AP002383.3 and AP001264.4 were designated JMJD2E and JMJD2F, respectively. C2HC2HC2- and C5HC2-type Cys (His) clusters were identified as the region conserved among JMJD2A (1064 aa), JMJD2B (1096 aa), and JMJD2C (1056 aa) proteins. JMJD2A, JMJD2B and JMJD2C consist of JmjN, JmjC, JD2H, and two TUDOR domains.
Alias Symbols: FLJ44906, KDM4B, KIAA0876, JMJD2B
Protein Interaction Partner: MED10
Protein Size: 1096 -
Molecular Weight
- 122 kDa
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Gene ID
- 23030
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NCBI Accession
- NM_015015, NP_055830
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UniProt
- O94953
Target
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