Karyopherin alpha 6 (Importin alpha 7) (KPNA6) Peptide
KPNA6
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979104
Quick Overview for Karyopherin alpha 6 (Importin alpha 7) (KPNA6) Peptide (ABIN979104)
Target
KPNA6
(Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-KPNA6 antibody (Catalog #: ARP54879_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Karyopherin alpha 6 (Importin alpha 7) (KPNA6) peptide
KPNA6 Reactivity: Human, Cow, Dog, Mouse, Pig, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
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Background
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The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. KPNA6 is a member of the importin alpha family.Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ11249, IPOA7, KPNA7, MGC17918
Protein Interaction Partner: ANP32A,BRCA1,CSE1L,KPNB1,RELB,STAT1,STAT3,TAF9,KPNB1,MEPCE,RELB,SPOP
Protein Size: 536 -
Molecular Weight
- 60 kDa
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Gene ID
- 23633
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NCBI Accession
- NM_012316, NP_036448
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UniProt
- O60684
Target
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