Mitogen-Activated Protein Kinase 14 (MAPK14) Peptide
MAPK14
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN979797
Quick Overview for Mitogen-Activated Protein Kinase 14 (MAPK14) Peptide (ABIN979797)
Target
MAPK14
(Mitogen-Activated Protein Kinase 14 (MAPK14))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MAPK14 antibody (Catalog #: AVARP06004_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))
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Background
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MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA
Protein Interaction Partner: CDC25B,NCF1C,ATF2,BCL2,CDC25B,CDC25C,CDX2,CREB1,CSNK2A2,CSNK2B,DDIT3,DUSP1,DUSP10,DUSP16,DUSP2,DUSP22,DUSP4,DUSP7,DUSP9,DYRK1B,EEA1,EEF2K,EIF4EBP1,ELK1,ELK3,ESR1,FAM48A,FKBP8,FLNA,GADD45A,GMFB,GRB2,HNF4A,HSF4,HTRA2,IRAK1,JDP2,JUNB,KRT18,KRT8,MAFA,MAP2K1,MAP2K3,MAP2K4,MAP2K6,MAP3K7,MAPK1,MAPK3,MAPK8,MAPKAPK2,MAPKAPK3,MAPKAPK5,MAX,MBP,MEF2A,MEF2C,MITF,MKNK1,MKNK2,NCF1,NCOA3,NFATC1,NFATC4,NUP153,PLA2G4A,PML,PPARGC1A,PTPN7,RET,RPS6KA4,SCN8A,SHC1,SLC9A1,SMAD3,SMAD7,SPAG9,STAT1,STAT4,STK39,TAB1,TRAF6,ZFP36L1,ZFYVE20,ZNHIT1,AKT1,ATF2,ATF2,ATF2,ATF2,CDC25A,CDC25B,CDC25C,CSNK2A1,DDIT3,DUSP1,DUSP10,DUSP10,DUSP16,DUSP4,DUSP6,DYRK1B,EGFR,ELK1,ELK1,ELK4,ELK4,ETV1,FUBP1,GMFB,HTRA2,JUN,KARS,KRT8,MAP2K3,MAP2K3,MAP2K6,MAP2K7,MAPK1,MAPK14,MAPK3,MAPKAPK2,MAPKAPK3,MEF2A,MKNK1,MKNK1,PLCB2,RPS6KA3,RPS6KA4,RPS6KA5,Rps6kb1,SLC12A2,SMAD7,SPAG9,STK39,TAB1,TAB1,TGFBR1,ZFP36L1
Protein Size: 360 -
Molecular Weight
- 41 kDa
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Gene ID
- 1432
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NCBI Accession
- NM_001315, NP_001306
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UniProt
- Q16539
Target
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