Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) Peptide
MBD1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979863
Quick Overview for Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) Peptide (ABIN979863)
Target
MBD1
(Methyl-CpG Binding Domain Protein 1 (MBD1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- EEDKEENKDD SASKLAPEEE AGGAGTPVIT EIFSLGGTRF RDTAVWLPRS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MBD1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
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Background
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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions, several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides, transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: CXXC3, PCM1, RFT
Protein Size: 629 -
Molecular Weight
- 69 kDa
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Gene ID
- 4152
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NCBI Accession
- NM_001204138, NP_001191067
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UniProt
- Q9UIS9
Target
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